Freddie Freeman hit the first game-ending grand slam in World Series history with two outs in the 10th inning to give the Los Angeles Dodgers a 6-3 victory over the New York Yankees in a dramatic opener Friday night.

Hobbled by a badly sprained ankle, Freeman, who holds Canadian citizenship and represents the country in international competition, homered on the first pitch he saw — an inside fastball from Nestor Cortes — and raised his bat high before beginning his trot as the sellout crowd of 52,394 roared.

It was reminiscent of Kirk Gibson’s game-ending homer that lifted Los Angeles over the Oakland Athletics in Game 1 of the 1988 World Series at Dodger Stadium — one of the most famous swings in baseball lore.

Gibson, sidelined by leg injuries, came off the bench and connected against Hall of Fame closer Dennis Eckersley.

Freeman, who missed three games during the National League playoffs because of the injury to his right ankle, didn’t have an extra-base hit this postseason until legging out a triple earlier on Friday.

“Actually felt pretty good,” Freeman said. “The last six days we treated it really well. I’ve been feeling pretty good. Right when I ran out to give high-fives to my teammates, I felt pretty good, because that was the first time I ran all week. So, ankle’s good.”

After the home run, Freeman ran over to his father.

“I was just screaming in his face. I’m sorry, dad,” Freeman said, laughing. “He’s been there since I was a little boy, throwing batting practice to me every day. So this is a moment, it’s my dad’s moment.”

In the top of the 10th, Anthony Volpe grounded into a fielder’s choice to shortstop, scoring Jazz Chisholm Jr. from third after he stole two bases, to give the Yankees a 3-2 lead.

The speedy Chisholm singled off Blake Treinen and then stole second. Following an intentional walk to Anthony Rizzo, Chisholm swiped third base uncontested as Treinen was slow to the plate with Max Muncy playing deep at third.

Tommy Edman made a diving stop to his left on Volpe’s grounder, but couldn’t get it out of his glove at first. He tossed to second to get Rizzo out as Chisholm came flying home with the go-ahead run.

Dodgers rally in extras

But the Dodgers weren’t done yet.

Gavin Lux walked against Jake Cousins with one out in the bottom of the 10th and went to second on Edman’s infield single to second. Defensive replacement Oswaldo Cabrera knocked down the ball with his glove but it leaked into the outfield.

That brought up star slugger Shohei Ohtani, a left-handed hitter. Yankees manager Aaron Boone went to his bullpen again for Cortes, a lefty starter who hadn’t pitched since Sept. 18 because of an elbow injury.

After missing the AL playoffs, Cortes was added to the World Series roster Friday.

Left fielder Alex Verdugo made a running catch in foul territory to retire Ohtani. Verdugo’s momentum sent him tumbling over the low retaining wall, advancing both runners one base because by rule it became a dead ball when Verdugo wound up in the stands.