Dan Sheehan will captain Ireland against Wales on his full return from injury.
The hooker will lead the team out for the first time.
In total, seven changes have been made from the win against Scotland.
Starting XV: Osborne; Hansen, Ringrose, Henshaw, Lowe; S Prendergast, Gibson-Park; Porter, Sheehan (capt), Clarkson; McCarthy, Beirne; O’Mahony, Van der Flier, Conan.
Replacements: McCarthy, Boyle, Bealham, Ryan, C Prendergast, Murray, Crowley, Aki.
